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    Keywords: MAGNETIC-RESONANCE ; PROGNOSTIC-FACTORS ; PREDICTION ; DIFFUSION ; GRADE ; CEREBRAL BLOOD-VOLUME ; TUMOR RESPONSE ; MICROVASCULAR PERMEABILITY ; AGENT EXTRAVASATION ; IMAGING BIOMARKERS
    Abstract: BackgroundTo compare intraindividual dynamic susceptibility contrast (DSC) and dynamic contrast enhanced (DCE) MR perfusion parameters and determine the association of DCE parameters with overall survival (OS) with the established predictive DSC parameter cerebral blood volume (CBV) in patients with newly diagnosed glioblastoma. MethodsPerfusion data were analyzed retrospectively, and included scans performed preoperatively at 3.0 Tesla in 37 patients (25 males, 12 females, 39-83 years, median 65) later diagnosed with glioblastoma. All patients received standard treatment consisting of surgery and radiochemotherapy. Images were spatially coregistered and maximum region of interest-based DCE and DSC parameter measurements compared and thresholds identified using multivariate linear regression, Pearson's correlation coefficients and using receiver operating characteristic analysis. Survival analysis was performed using Kaplan-Meier curves. ResultsWhile both, elevated volume transfer constant (K-trans) (〉0.29 min(-1); P = 0.041) and CBV (〉23.7 mL/100 mL; P 〈 0.001) were significantly associated with OS, elevated CBV was associated with worse OS compared with elevated K-trans. K-trans was significantly correlated with the leakage correction factor K-2 but not with CBV. ConclusionThe combined use of DSC and DCE MR perfusion may provide additional information of prognostic value for glioblastoma patient survival prediction. As K-trans was not tightly coupled to CBV, both parameters may reflect different stages in the pathogenetic sequence of glioblastoma growth.
    Type of Publication: Journal article published
    PubMed ID: 25244574
    Signatur Availability
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