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    HNO 56 (6), 594-602 
    Keywords: CANCER ; EXPRESSION ; SURVIVAL ; tumor ; carcinoma ; CELL ; Germany ; THERAPY ; DISEASE ; NEW-YORK ; SITES ; GENE ; GENES ; DNA ; BIOMARKERS ; SEQUENCE ; SEQUENCES ; ALPHA ; prevention ; PROGRESSION ; ASSAY ; DNA methylation ; inactivation ; TUMOR-SUPPRESSOR GENE ; REGION ; REGIONS ; PHENOTYPE ; SQUAMOUS-CELL CARCINOMA ; HEAD ; CARCINOMAS ; STRATEGIES ; squamous cell carcinoma ; OUTCOMES ; HYPERMETHYLATION ; C/EBP-ALPHA ; molecular ; CELL CARCINOMA ; TUMOR-SUPPRESSOR ; THERAPIES ; CANDIDATE GENES ; HNSCC ; CPG ISLANDS ; biomarker ; SUPPRESSOR ; PROMOTER HYPERMETHYLATION ; USA ; LOSSES ; EPIGENETICS ; CANDIDATE ; CANCERS ; REDUCED EXPRESSION ; DNA-METHYLATION ; modification ; tumor suppressor ; epigenetic ; DNA METHYLATION PATTERNS
    Abstract: For years, head and neck squamous cell carcinomas (HNSCC) have been among the leading cancers worldwide. Despite considerable efforts, the 5-year survival rate for HNSCC has not changed significantly. To improve this situation, it is necessary to understand the fundamental biological processes leading to the disease and its progression. In addition to known genetic changes in HNSCC, molecular cytogenetic investigations have identified chromosomal regions of gains and losses, but many of the responsible candidate genes have yet to be identified. Furthermore, recent results indicate the importance of epigenetic modifications in HNSCC, such as DNA methylation. Several genes, including the tumor suppressor CDKN2A and other candidates such as DAPK1, MGMT, TIMP3, TCF21, and C/EBP alpha, have been found to harbor hypermethylated regulatory sequences that lead to reduced expression or gene silencing. Hypermethylation in such genes could be used not only as biomarkers for the early detection of HNSCC but also to improve prevention strategies and therapy outcomes
    Type of Publication: Journal article published
    PubMed ID: 18483718
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