Supercritical fluid Chromatography
Light scattering detection
Analytical Chemistry and Spectroscopy
Wiley InterScience Backfile Collection 1832-2000
Chemistry and Pharmacology
The evaporative light scattering detector (ELSD) has been used in pharmaceutical analysis by liquid and supercritical fluid chromatography. An ELSD equipped with interchangeable interfaces enables the use of various eluents (UV- or non-UV-absorbing) in isocratic or gradient mode. Analyses were performed on several non-UV-absorbing excipients and active substances. The narrow spread of the response factors of the various compounds investigated has indicated that the detector is suitable for direct raw quantitation of unknown samples in stability studies.
Type of Medium: