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  • 1
    ISSN: 0075-4617
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Basic Di- and Tri-hydroxyanthraquinone Derivatives as Model Compounds for Anthracycline AntibioticsAs model compounds for studies of the interaction of different anthracycline antibiotics with deoxyribonucleic acids, several 1,4-di- and 1,4,5-tri-hydroxyanthraquinones with basic groups in 2-, 3- and 6-position were prepared by applying the alkylation procedure for hydroxy-anthraquinones developed by Marschalk et al.1) as well as the Mannich reaction.
    Notes: Als Modellverbindungen zum Studium der Wechselwirkungen verschiedener Anthracyclin-Antibiotika mit Desoxyribonucleinsäure wird eine Reihe von 1.4-Di- und 1.4.5-Tri-hydroxy-anthrachinonen mit basischen Resten in 2-, 3- und 6-Stellung hergestellt. Dabei kommen das von Marschalk und Mitarbeitern1) entwickelte Alkylierungsverfahren für Hydroxyanthrachinone sowie die Mannich-Reaktion zur Anwendung.
    Type of Medium: Electronic Resource
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