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  • 1
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 754 (1972), S. 107-112 
    ISSN: 0075-4617
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Antamanide, X. The Tyrosine6-Analogue of AntamanideAn analogue 1 of antamanide (2) with tyrosine instead of phenylalanine in position 6 has been synthesized by fragment condensation using O-benzyl tyrosine. 1 and its methyl ether 1b have the same protecting activity as 2 against phalloidine in the white mouse (0.5-1 mg/kg), whereas the O-benzyl derivative 1a is ineffective.
    Notes: Ein Analoges 1 des Antamanids (2), welches in 6 Position Tyrosin anstelle von Phenylalanin enthält, wurde unter Verwendung von O-Benzyl-tyrosin durch Fragmentkondensation synthetisiert. 1 schützt die weiße Maus mit der gleichen Dosis (0.5-1 mg/kg) gegen Phalloidin wie 2; die O-Methyl-Verbindung 1b ist ebenso wirksam, während die O-Benzyl-Verbindung 1a keine antitoxische Wirkung besitzt.
    Type of Medium: Electronic Resource
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