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  • 1
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 755 (1972), S. 51-57 
    ISSN: 0075-4617
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Thalidomide Analogues, IVThe synthesis and identification by thin-layer chromatography of the potential metabolities of a non-teratogenic congener of thalidomide (test compound „K-2004“, 1) are described. The increased resistance against hydrolysis of 1 compared with thalidomide (2) is demonstrated and a possible connection with the altered biological activity is discussed.
    Notes: Die Synthese und dünnschichtchromatographische Identifizierung der potentiellen Metaboliten eines nicht teratogenen Thalidomid-Abkömmlings (Testsubstanz „K-2004“, 1) werden beschrieben. Die erhöhte Hydrolysebeständigkeit von 1 im Vergleich zu Thalidomid (2) wird demonstriert und ein möglicher Zusammenhang mit der veränderten biologischen Aktivität diskutiert.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
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