Wiley InterScience Backfile Collection 1832-2000
Chemistry and Pharmacology
Four new penta- and hexacyclic antifungal and antibacterial metabolites, the palmarumycins CP1-CP4 (1-4), were isolated from Coniothyrium palmarum. In these structurally unique antibiotics, a 1,8-dihydroxynaphthalene unit is connected by a spiroacetal to another partially reduced naphthalene unit. The structure of the pentacyclic palmarumycin CP3 (3) was confirmed by X-ray structure analysis.
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