Wiley InterScience Backfile Collection 1832-2000
Chemistry and Pharmacology
Treatment of the title compounds with either H3PO4 or BF3 · Et2O affords the bridged tricyclic lactones 3 and 7 as main products (57 and 70% yield, resp.). This is an efficient and novel access to specifically functionalised molecules possesing the bicyclo[3.2.1]octane skeleton. Lactones 4 and 5 and the bicyclic ketone 6 were formed as by-products (2, 7, and 10% yield, resp.).
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