Wiley InterScience Backfile Collection 1832-2000
Chemistry and Pharmacology
A regioselective cyclohexannulation procedure, whose key step involves the [4 + 2] cycloaddition of dienamines 12-24 with methyl acrylate, allows the conversion of cycloalkanones 1-11 to bicyclic dienoates 25 - 37. The chemistry of 26 is briefly examined and, in the context of organoleptic studies concerning functionalised 5,5,9-tri-methyldecalins, the transformation of 37 to ketones 44 and 46 as well as to acetates 53-56 is described.
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