Wiley InterScience Backfile Collection 1832-2000
Chemistry and Pharmacology
Solvent effects on the absorption spectra of N-(p-nitrophenyl)dimethylenediamine (Ia), N-(p-nitrophenyl)trimethylenediamine (Ib), N-(p-nitrophenyl)tetramethylenediamine (Ic). N-methyl-N-(p-nitrophenyl)tetramethylenediamine (II), N-butyl-p-nitroaniline (III) and N-(o-nitrophenyl)trimethylenediamine (IV) were studied at different temperatures. Whereas II, III and IV do not show any variation in their spectra characteristics with changes in temperature, I shows a hypsochromic shift with a hypochromic effect when the temperature is increased. The Kamlet and Taft solvatochromic comparison method was applied. A strong effect of the β parameter on I and III was interpreted as being due to the hydrogen bond donor ability of the H atom in the aromatic amino groups. In I, the β influence increases with increase in temperature. These facts are explained by proposing the formation of intramolecular hydrogen bonds between amine groups in all compounds I, besides the intermolecular interactions between compounds I and the solvent. On the other hand, the values of vo, s and b for Ib are smaller than the corresponding values for Ia and Ic. Since in Ib a six-membered ring may be formed, a more stable bond is expected. Comparative 1H NMR of the aniline hydrogen for I and IV (in non-hydrogen bond acceptor solvents) shows a particular downfield chemical shift for I which suggests hydrogen bond formation. Since this effect is independent of concentration, the hydrogen bond is assumed to be intramolecular, in agreement with solvatochromic and thermochromic studies. These conclusions were corroborated by IR spectroscopy in the solid state and in chloroform solutions.
Type of Medium: