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  • 1
    ISSN: 1432-2013
    Keywords: Kidney ; Experimental Hypertension ; DOCA ; Specific Reabsorption Capacity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Rats were made chronically hypertensive by unilateral nephrectomy, repeated injections of desoxycorticosterone-acetate and offering saline as drinking fluid (DOCA-rats). Unilaterally nephrectomized animals (Nephrex-rats) were used for control. Compensatory renal hypertrophy was greater in DOCA-rats than in Nephrex-rats. Diameter and length of the proximal convolute in the DOCA-group increased more than in Nephrex-rats. GFR per unit kidney weight in the DOCA-group remained unchanged as compared to untreated Wistar-rats but increased significantly in Nephrex-animals. the water and sodium load of each nephron had doubled in both groups. Nevertheless, there were no substantial changes in the fractional water and sodium reabsorption in the different segments of the nephron of DOCA-rats as compared to normal animals. In Nephrex-rats fractional sodium and water reabsorption were increased in the proximal tubule and diminished in the loop of Henle and in the distal tubule. In Nephrex-rats an indirect correlation was found between blood pressure and both water reabsorption and the transit time of Lissamine green in superficial loops of Henle but no such correlation could be found in the DOCA-group. Determination of the specific reabsorption capacity of the proximal tubules during free-flow or using the split-drop technique yielded identical values in all animals studied.
    Type of Medium: Electronic Resource
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