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  • 1
    Electronic Resource
    Electronic Resource
    Chromatographia 32 (1991), S. 373-378 
    ISSN: 1612-1112
    Keywords: Chromatography ; Quantitative analysis ; Resolution of overlapped peak pairs ; Exponentially-modified Gaussian function
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary Based on the ratio of two apparent heights and an empirical correction factor, a method is presented for quantitation of peak areas of severely overlapped pairs. This method can be applied to a wide range of area ratios and peak asymmetries, provided there exists a clear and precise valley-except for shoulder peaks. The relative errors of the first peak are usually within ±3% and theoretical relative error limits are −7.0% to +5.5%. Peak asymmetry of a severely overlapped pair can be determined using the ratio of the front half-width to the rear half-width at 10% peak height of an overlapping profile. The asymmetry so determined is an apparent one and the relative errors are −4% to +5.3% for peaks with 90% relative valley, depending on area ratio, degree of overlap and asymmetry. An empirical area equation for the first peak involving area ratio, asymmetry, resolution and the area measured by a perpendicular drop algorithm is also developed.
    Type of Medium: Electronic Resource
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