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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Injection of CBA mice with H-2-compatible lymphoid cells from C3H hybrids induces a specific reduction of the mixed lymphocyte culture (MLC) response of their lymphoytes. This is not the case after injection of H-2-disparate C3H-hybrid cells, presumably because they are rapidly eliminated due to the immune response of the host. This investigation shows that CBA mice injected with CBA × C57B1 cells (H-2-disparate) at an age of 0–3 days, but not older, develop a specifically reduced MLC response after infusion of C3H × C57B1 cells as adults, indicating that they were tolerant to the C57B1-determined antigens. However, lymphocytes from such mice showed a normal reactivity against C57B1 as assessed by MLC, graft-versus-host tests, and capacity to produce specific antibodies.
    Type of Medium: Electronic Resource
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